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When RCTs are unavailable, drug target MR can provide high-level human genetic evidence to support drug repositioning and the identification of adverse effects [24]

10.1016/j.neulet.2009.02.041 40 BharwaniA.MianM

One widely quoted study resulted in a 15% weight loss in a group of nearly 2,000 adults who participated, and most other findings seem to settle on the 15% number

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