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Increased Sun Sensitivity: The ingredients in the serum, particularly Kojic Acid and Alpha Arbutin, may increase the skin's sensitivity to sunlight

First, the complex appears to act as a copper transporter, delivering ionic copper to cutaneous cells where it may activate copper-dependent enzymes involved in extracellular-matrix remodeling and angiogenesis

Selenium depletion in farmed soils where our vegetables are grown and animals pasture can also play a factor in this

As an alternative possibility, the GPx1 deficiency in intestinal macrophages could be due to increased utilization of selenium for selenoprotein production elsewhere as serum GPx activity was increased in patients with active CD