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Symptoms of a Vitamin B-Complex Deficiency Vitamin B12 deficiency can cause a variety of symptoms, and they can vary depending on the severity and duration of the deficiency

Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

Epidemiologic studies have shown a link between vitamin B12 and folate deficiencies and increased metabolic risk

If you are going to do this, you will experience some serious side effects from an overdose