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PLP acts as a cofactor for numerous enzymes involved in amino acid metabolism, particularly those associated with neurotransmitter synthesis, like serotonin, dopamine, and gamma-aminobutyric acid (GABA) (5759)

In initial animal studies, that elucidated the role of glucose metabolism in insulin secretion, the rodent GLUT2 transporter was identified as the major sensor and transporter of glucose in pancreatic -cells

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