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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

Potential Side Effects and Considerations Though GLP-1 drugs offer exciting potential, they also come with side effects to consider, including: Nausea or vomiting Gastrointestinal upset Potential risk of pancreatitis Mood changes or fatigue in some users Because these medications act on complex systems within the brain and body, you should only use them under close supervision from a qualified medical provider

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