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In the Phase 2 trial, researchers looked at subjects with MASLD and found that the highest dose of retatrutide led to an 80% or greater reduction in liver fat content in a majority of participants

In addition, exposure to sweeteners has been shown to alter fermentation profiles and metabolism in vitro, indicating a connection between sweetener exposure and modifications in both microbiota composition and microbial metabolic processes (Vamanu et al, 2019)