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Duration of therapeutic effects : The effects typically last for 2-4 hours, making it ideal for short-term use

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This interaction has been confirmed clinically: in renal transplant recipients, 0.2 g berberine three times daily for three months increased cyclosporine AUC by 34.5 % and prolonged its half-life by 2.7 h [150,151], while in heart transplant patients, a 25 % increase in cyclosporine blood levels was observed [152]