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G.OrtizR

& Dobbins, J

[8] According to mathemetical modeling, the futile cycle could act as a dampener in the broader network of folate-mediated one-carbon metabolism, stabalizing it against stochastic noise from folate deficiency and/or reduced MTHFR activity due to genetic variation

Although the exact mechanism by which this stimulates ovulation is not known, it is thought the reduction in ovary size and removal of some follicles results in reduced androgen production, enhanced ovarian blood flow, increased FSH secretion, and restored HPO signaling