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Telomerase activation is its signature mechanism: Epitalon can activate telomerase and lengthen telomeres in human cells, extending their replicative lifespan beyond the Hayflick limit, while preserving youthful morphology and function, though this benefit must be weighed against potential cancer risks

Additionally, the mutant huntingtin protein can impair the function of the transcription factor PGC-1, which is crucial for the regulation of antioxidant defenses and mitochondrial biogenesis

Abstract Wilson disease (WD), a rare autosomal-recessive disorder caused by impaired copper metabolism, leads to hepatic dysfunction and copper overaccumulation, debilitating neurological symptoms

doi: 10.1038/nrc3278 87 SunXOuZChenRNiuXChenDKangRet al