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When semaglutide or tirzepatide activates these receptors, they influence dopamine and serotonin pathways that regulate emotion, stress response, and anxiety levels

A large study that compared tirzepatide to semaglutide showed that in non-diabetic, overweight adults, the risk of gastroparesis was much higher in semaglutide recipients compared to tirzepatide

Klinic Patient Testimonials See what the Klinic community is saying Crystal Landrum How Klinic's Metabolic Health Program Works Get matched with a licensed provider Fill our a short form and we will verify your insurance and match you with the right provider Complete an online visit Answer questions about your weight loss goals, medical history, and current medications and our provider will create a personalized treatment plan for you Medication shipped to you and Prior Authorization Support In case medication is prescribed, we will handle the prior authorization process with your insurer and you will get medication delivered to your door, with ongoing provider support

Beyond glycemic control, these medications initially slow gastric emptying, though this effect may diminish over time with long-acting formulations