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In 2009, the US Food and Drug Administration designated pyridoxamine as a pharmaceutical, when it became the active ingredient in Pyridorin, a drug designed by Biostratum Inc., and investigated for possible utility in diabetic nephropathy due to its ability to decrease the production of advanced glycation end products (AGE) in animal models of diabetes

There are currently four IDO inhibitors under clinical development and more in preclinical testing [130]

Therefore, the metabolic phenotype of NKCC2A KO mice likely stems from complex, age-dependent and long-term functional interactions between the brain, pancreatic islets, kidneys and intestines as well as other tissues where NKCC2 may be expressed, even in minimal quantities relative to the kidneys

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