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A recent meta-analysis conducted on elderly T2D patients (15 studies, n = 11,679) evidenced that a combination of GLP-1RAs with SGLT2is (with an intervention period of at least six months), beyond demonstrating a positive safety profile, gave more benefits over monotherapy in terms of glycemic control, weight management, and CV protection [137]

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Our results support that the addition of setmelanotide significantly increases weight loss in this population, associated with good tolerability and safety, demonstrating that its benefits outweigh its potential risks, taking into account the evidence of safety and efficacy evaluated in this study, as well as the severity of the disease that the drug is intended to treat