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A hypothesis could therefore be that the ASG-10 cells have higher amount of mitophagy and mitochondrial recovery than the RTgill-W1 cells and thus less sensitive to the rotenone-induced toxicity

103,104,105,106 However, a variety of stimuli, including nutrient perturbation, genotoxic stress, infection, pollutants and xenobiotics, trigger ROS overproduction, resulting in excessive oxidant challenge (oxidative distress)