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Current evidence supports glutathione's potential as a depigmenting agent but underscores the need for rigorous, large-scale clinical trials to establish long-term safety, optimal dosing, and standardized applications, and until such data are available, clinicians and consumers should exercise caution to ensure safe and effective dermatological practices, particularly with intravenous use

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P., Cell Biochem

The short answer, which the rest of this reference will unpack carefully, is that peptide bioregulators are a genuinely interesting scientific concept with a real, decades-long body of published work behind them but one whose most exciting claims (tissue specificity, epigenetic gene regulation, telomerase activation, lifespan extension) rest heavily on studies from a single research school, with limited independent replication and very few rigorous double-blind randomized controlled trials