companies working on glp-1 drugs 2025’s Breakthrough Obesity Treatments: Top & Innovations The Biggest Winner of GLP-1

10.1080/00365521.2022.2041084 [DOI] [PubMed] [Google Scholar] 63.Wu HY, Tang XQ, Mao XF, Wang YX (2017) Autocrine Interleukin-10 mediates Glucagon-Like Peptide-1 receptor-Induced spinal microglial beta-endorphin expression

While the cohort was relatively small and sample sizes differed substantially (87.9% GLP-1 vs 12.1% comparator), the authors reported an increased risk of bowel obstruction in those treated with GLP-1RAs (HR 4.22 [95% CI 1.02-17.40])

A large new study suggests that GLP-1 receptor agonists may offer more protection against dementia in patients with type 2 diabetes mellitus than metformin, the long-established first-line treatment

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