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Challenges in Cardiovascular Evaluation and Management of Obese Patients: JACC State of the Art Review JACC Trends and Disparities in ObesityRelated Mortality Among U.S. Adults: A CDC WONDER Analysis (19682025) Ahmed 2026 Obesity Science & Practice Wiley Online Library Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases Research Do GLP 1 Medications Speed Up Metabolism? What Research Shows Fella Health

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Results: Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic/epigenetic regulators and reproductive-tract/gut microbiome dysbiosis