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Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., The sub-organellar localization of GCL raises questions about redox regulation of glutathione biosynthesis in plants

Right-upper-quadrant tenderness may be present

Elevated serum CK levels may be observed in primary carnitine deficiency and in fatty acid oxidation disorders

Unlike aspirin, inhibition of cyclooxygenase (COX) activity by paracetamol is biphasic and requires glutathione and hydroquinone as cofactors [40]