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Description

It exists in two primary isomeric forms: the *trans* isomer, which is typically more stable, and the *cis* isomer, which can be induced by UV light

The landmark 2023 Nature Aging study by Castner et al

doi: 10.1159/000542419 51

The activation of NF-B leads to the upregulation of RAGE expression, resulting in sustained stimulation and the promotion of signaling mechanisms that contribute to cellular damage 106