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Unlike the concept of a single universal maintenance dose, Zepbound's maintenance dosing is individualized , with patients potentially maintaining on any dose from 5 mg to 15 mg once weekly depending on their response and tolerance

The pathogenesis of DN is multifaceted, involving hyperglycemia, dyslipidemia, oxidative stress, mitochondrial dysfunction, and inflammation, which collectively damage peripheral nerves

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Altogether, this contributes to neuronal apoptosis or cell death (Zaltieri et al., 2015