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J., 2021, vol

Ageing has been associated with various metabolomic profiles including elevated isoleucine, acetylcarnitine, pipecolate, methionine, glutarylcarnitine, 5-hydroxytryptophan, ketoleucine, and hippurate with decreased methylthioadenosine and 3-methyladenine 43 , markers of the carnitine shuttle, sucrose, biopterin, vitamin E metabolism, tryptophan, and tyrosine 44 and elevated cysteine, pantothenic acid, 5-hydroxyindoleacetic acid (5-HIAA), aspartic acid, and glutamate and reduced asparagine and glycerophosphocholine 45

doi:10.1155/2015/648108 Staresinic M, Sebecic B, Patrlj L, et al

Z-stack images were taken on Leica TCS SP8-DLS using a HC PL APO CS2 63x/1.40 oil objective and 12-bit depth with laser intensities adjusted to avoid signal saturation