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Data across multiple trials consistently shows that dual agonists (GLP-1 plus GIP) produce lower nausea rates than GLP-1-only compounds

The adverse reactions, excluding hypoglycemia, reported regardless of investigator assessment of causality in 5% of patients treated with JANUVIA 100 mg daily and more commonly than in patients treated with placebo, are shown in Table 1 for the clinical trials of at least 18 weeks duration