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Due to this, the production of melanin stops

In addition, fumaric acid may affect the catabolism of tyrosine and inhibit the enzyme activity therein, which ultimately leads to an elevation of tyrosine and so on in biochemical tests [85]

Although the VPA model effectively recapitulates key ASD phenotypes, future work must validate these findings in genetic subtypes (e.g., Shank3 KO) and decipher causal microbiota-neuroimmune crosstalk via fecal transplantation