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MT1 and MT2 are seven transmembrane-spanning proteins belonging to the G-protein-coupled receptor (GPCR) superfamily 24 , which exhibit high-affinity binding and could be activated at low concentrations of melatonin (pMnM) 25

Unlike the alteration of phenylalanine level, the abundances of arginine in both CSF and serum biospecimens showed no apparent differences between MS-affected Caucasian subjects and matched healthy controls (38), whereas, we found that the level of beta-alanyl-L- arginine increased dramatically in Chinese patients with MS compared to healthy subjects

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Weis et al