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Horvath TL, Castaeda T, Tang-Christensen M, Pagotto U, Tschp MH

Recent Developments: 2025: Eli Lilly received FDA approval for tirzepatide (Zepbound) as a treatment for moderate-to-severe obstructive sleep apnea in adults with obesity the first pharmacotherapy approved for this indication expanding tirzepatide's approved uses beyond metabolic conditions into a respiratory indication affecting over 30 million Americans and supported by SURMOUNT-OSA trial data showing 63% reduction in apnea-hypopnea index

For missed Wegovy doses, consult the manufacturers instructions

Leptin deficiency has been shown to impair AMPK-PGC1 signaling in skeletal muscle (42) and promote lipid overload, incomplete -oxidation, and elevated mitochondrial reducing pressure conditions that may blunt the improvements in OXPHOS coupling efficiency typically seen with weight loss (43, 44)