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Finally, excessive glucose flux through the hexosamine pathway leads to UDP-GlcNAc accumulation and subsequent O-GlcNAcylation of serine/threonine residues on antioxidant enzymes, like SOD, reducing their activity (Paneque et al., 2023)

Khavinson's group reported that epithalamin administration restored melatonin rhythmicity in elderly subjects, shifting the nighttime melatonin peak earlier and increasing amplitude 4