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Proceedings of the National Academy of Sciences, 110(12), 48044809

Taken together, evidence from neuroscience, human research, and clinical practice suggests meaningful overlap between obesity and addiction-related mechanisms. Lorenzo Leggio, MD, PhD, clinical director, National Institute on Drug Abuse, Bethesda, Md

If the price is high relative to the benefit, NICE can restrict access to specific patient groups (for example, only those with very high BMI or particular comorbidities), or reject NHS use altogether