Presenilin 1 Polyclonal Antibody, 100ul Purification Ligand-activated LXRs form obligate heterodimers

Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs

which is one of several factors that influence the basal activity of G-protein signaling systems

Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A

This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A

Presenilin 1 Polyclonal Antibody, 100ul Purification Ligand-activated LXRs form obligate heterodimersAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.