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Regular provider communication during titration ensures safe, individualized progression

Even if the FDA ultimately denies the petition (which it does in the vast majority of cases where the petition appears primarily motivated by competitive concern rather than genuine safety issues), the review process takes time often three to six months during which the competitors approval is effectively delayed

"So the thought is, if you're getting pretty close to semaglutide's weight loss in almost roughly half the time with orforglipron, you will probably exceed it." Chen said the hope is that orforglipron leads to a reduction similar to that of Eli Lilly's injection tirzepatide, which resulted in weight loss of around 22% after 72 weeks