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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors

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For a detailed look at how quickly effects manifest, the dedicated guide on how fast semaglutide works breaks down the pharmacokinetics in detail, while how long it takes semaglutide to work addresses the specific question of onset timing

Mounjaro is made by Eli Lilly and contains the same active ingredient (tirzepatide) as Zepbound