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In the 536 bp site of the proximal promoter of GGT, a binding site exists between p50, TNF- and Sp1, regulated by the activation of the NF-B signaling pathway, thereby promoting expression of GGT and inducing inflammatory response (Fig

For example, El-Lebedy (2019) reported reduced circulating METRNL levels in individuals with type 2 diabetes and obesity compared with controls, whereas Dadmanesh et al