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Bioessays (2018) 40:1800027

Clinically BPH is manifested as lower urinary tract symptoms (LUTS) and consisting of voiding and storage symptoms such as slow urinary stream, splitting or spraying of urinary stream, recurrent urinary stream, straining to void and terminal dribbling, hesitancy, urgency, increased frequency, and incontinence

These coordinated changes suggest that cold-acclimated T cells transition from a proliferative and stress-responsive state toward a cellular state optimized for sustained transcriptional and translational activity

These morphological alterations are consistent with reactive astrocytes, aligning with the RNA-seq findings of elevated MAOB and GFAP expression in PTSD and resembling astrocytic alterations observed in other psychiatric disorders