labial melanotic macule on lip Pigmented macular lesion Mucosal melanocytic macules

194,195 Exercise Although particularly intense exercise, especially in hot environments, can be a contributing factor to IBS (as discussed in section on causes and risk factors for IBS), exercise can also be beneficial for IBS patients

Time frames are different

In contrast to patients with other nuclear encoded Complex I defects who typically have a severe clinical presentation and associated early death, it has been suggested that pathogenic variants in the FOXRED1 gene result in partial loss of function and are probably hypomorphic due to the longer survival of patients [61]

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