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As a 2022 report noted, "obesity remains the most important risk factor for the incidence and progression of osteoarthritis." According to Bliddal, the researchers launched the study to answer this question: "Would a highly effective anti-obesity medication improve KOA to a clinically meaningful degree?" Other studies had tackled the question with inconsistent results, he said

In accord with this, Pyy -null mice, or islets in which the Y1 receptor is absent, hypersecrete insulin (56, 57)

J Biol Chem 285: 1438914398, 2010