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Without adequate vascularization, fibroblasts can't proliferate or synthesize collagen efficientlywhich is why ligaments with poor baseline blood supply (like the ATFL) heal slowly and incompletely

multiple lesions may also be seen The borders of the lesions are usually irregular When Laugier-Hunziker syndrome is present, the melanotic macules may involve the nail units too The underlying skin or mucosal surface usually remains unaffected

This can lead to prolonged development timelines and increased costs for pharmaceutical companies

Cuando se administra AP los nutrientes no llegan al intestino delgado en forma regular, es decir, en bolos, de modo que no se produce la estimulacin fisiolgica del sistema enterohormonal y ocurre una situacin anmala en el tubo digestivo