retatrutide semaglutide vs Ozempic: Why the Weight Loss Gap Is So Large CagriSema vs Retatrutide 2026: Approval

Crawford, E

LIR was also shown to cross the BBB following intraperitoneal administration at 25 and 250 nmol/kg, while no measurable increase in brain levels was detectable at the lowest tested dose, 30 min post-injection, nor at a later time point (3 h), even with the highest dose suggesting that LIRs brain penetration is both dose- and time-dependent (Hunter and Hlscher, 2012)

This really highlights the difference between a direct trigger and an indirect influencer

There is a theoretical basis for benefit, as GLP-1-based therapies have been shown to improve hormonal balance and menstrual regularity in women with PCOS through weight loss and improved insulin sensitivity