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Improves satiety signaling reduces food cravings and binge tendencies

Treating it as a series of isolated problems produces, at best, partial solutions

De Jonghe et al., Motor disturbances/hypoactivity Another concern with therapies targeting the mesolimbic system is that the behavioral outcomes obtained are not specific to ingestive behavior and mediated via a general increase or decrease in physical activity

Targeted Local Applications While subcutaneous injection provides systemic distribution, injecting closer to specific target areas may enhance local effects