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These compounds can be grouped in medications targeting (1) metabolic derangements including excess bodyweight, (2) inflammation and oxidative stress, and (3) dysregulation of the gut-liver axis (42)

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58 Although speculative, this may occur via a decrease in the activity of coloprotective metallothionein 59 in the intestinal mucosa, or impairment of T- and B-cell interaction 60 that may contribute to gut dysbiosis favoring ASD-associated bacteria