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Schimke RT

The rationale is that the two molecules are not equipotent at nominally similar doses, and the titration schedule for tirzepatide requires a fresh start to minimize GI risk

Of course, the most obvious clue to an upper gastrointestinal bleed is if they are vomiting blood in front of you, however this is not always the case, and sometimes all you might get is a vague history of dark vomit altered blood or coffee-ground vomit, or an episode of dark stools

A systematic review and meta-analysis of randomized trials also suggested that there was a risk of key safety outcomes (severe hypoglycemia, retinopathy, or pancreatic adverse reactions) with GLP-1RAs, but there was no increase [30]