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Neuroscience 180, 111121

using in vivo fiber photometry demonstrated that both GIP and GLP-1 analogs at pharmacologic doses inhibited AgRP neurons in proportion to their anorexigenic action

Weight Loss: The average percent weight loss from patients starting weight after these 14 months at the maintenance dose was: -8% weight loss from baseline body weight at 56 weeks at the 3.0mg dose By contrast, the control group saw an average 2.6% weight loss compared to their baseline weight at the 56-week point

Insufficient protein intake during weight loss accelerates loss of lean muscle mass , which can reduce metabolic rate, impair physical function, and compromise long-term weight management