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Proceedings of the National Academy of Sciences , 114 (9), 2096-2098

The condition was first described in 1940 as a clinical syndrome affecting women, marked by subcutaneous deposition of fat in the buttocks and lower extremities, and edema unresponsive to typical weight loss interventions.1 Despite its early identification, lipedema remained largely underrecognized for decades and was frequently misdiagnosed as obesity, lymphedema, venous insufficiency, or even cellulite

Writing in the journal Jama Internal Medicine the researchers which included experts from the pharmaceutical company that makes Mounjaro, Eli Lilly report how they analysed data from the Surmount-4 trial, a study involving participants with obesity or who were overweight and had at least one weight-related health problem