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The trial's joint chair, Professor Rury Holman of Oxford University, told delegates at the ADA that the study "provides reassurance that sitagliptin may be used safely to improve blood glucose levels in a diverse group of type 2 diabetes patients at high cardiovascular risk without impacting on rates of cardiovascular complications or heart failure." AZ added to the debate at the ADA with the presentation of data from a real-world study which found no evidence of increased risk of hospitalisation for heart failure with Onglyza compared to Januvia in patients with and without established CV disease

Moreover, SGLT2is have been demonstrated to reduce the total circulating volume, improve sodium balance and increase haematocrit, which may improve oxygen delivery to tissues [11, 40]

J Colloid Interface Sci 505:577584 Sharma AC, Jana T, Kesavamoorthy R, Shi S, Virji M (2004) A general photonic crystal sensing motif: creatinine in bodily fluids

In another study, researchers discovered that tirzepatide treatment, when combined with a decrease in circulating levels of branched-chain amino (BCAA) and keto (BCKA) acid metabolites linked to the development of systemic insulin resistance (IR) and T2DM improves insulin sensitivity in obese mice and humans with T2DM [82]