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While rare cases of idiosyncratic drug-induced liver injury have been reported, there is no established direct link between GLP-1 receptor agonists and serious hepatotoxicity in patients with normal baseline liver function

12 , 14 , 18 , 24 While these exclusions help reduce confounding, they do not eliminate it entirely, and attributing the observed findings solely to GLP-1 RA use remains open to debate

While the trend dipped in post WW2 era, the accessibility of package holiday in the eighties and nineties saw the re-emergence the tan and by 2000, a survey revealed that 50 percent of Britons admitted that returning with a tan was the single most important reason for actually going on holiday

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