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Inhibition of SGLT-1 in the small intestine causes more glucose transport to the distal intestine and colon, resulting in greater fermentation of glucose to SCFAs by luminal bacteria and increased sustained release of GLP-1 in the distal intestine [174] (Fig

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Because of its investigational status, retatrutide should not be viewed as an alternative that is automatically available or suitable

Tirzepatide may provide slightly stronger HDL cholesterol improvement and insulin sensitivity gains, particularly in people with metabolic dysfunction