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12 The impact of these additional five years due to PTA and PTE is profound: Novo Nordisk is projected to earn an estimated $166 billion from Ozempic and Wegovy as a result of this extended period of patent protection, which spans from March 2026 to December 2031

[117] However, the safety and appropriate use of exogenous melatonin supplementation during pregnancy remain areas of ongoing research and clinical uncertainty