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Most side effects are gastrointestinal in nature and often occur when the dose is being increased

The emerging triple agonist retatrutide shows even greater weight loss than semaglutide or tirzepatide in early trials

The FDA label for Rybelsus specifies: take on an empty stomach with no more than 4 oz of water, wait at least 30 minutes before eating, drinking anything else, or taking other oral medications [5]