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4 The consequence is the evident gap between the theory (reestablished homeostasis, integrative beneficial effects) and the practical realization (limited beneficial activity of the given agent with the harmful effect as well)

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doi: 10.3389/fendo.2025.1734431 Received 28 October 2025 Revised 26 November 2025 Accepted 02 December 2025 Published 17 December 2025 Volume 16 - 2025 Edited by Sandhya Srikant Visweswariah, Indian Institute of Science (IISc), India Reviewed by Gargi Meur, National Institute of Nutrition (ICMR), India Nikhil R