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Mechanisms and possible hepatoprotective effects of glucagon-like peptide-1 receptor agonists and other incretin receptor agonists in non-alcoholic fatty liver disease

Severe side effects of the medication are: Severe gastrointestinal problems Low blood sugar levels (hypoglycemia) Changes in vision due to diabetic retinopathy pancreatitis Gallbladder problems Hypoglycemia Allergic reaction to the medication Severe stomach pain Risk of aspiration during sedation or anesthesia Mood and behavioural changes Suicidal ideation Limitations Semaglutide is contraindicated for patients with a history or family history of thyroid cell tumors (MTC) and endocrine cancers (MEN 2 syndrome) because the medication increases the risk of these tumors in rodent studies

NCT04657016

Semaglutide, tirzepatide, and high dose dulaglutide have been deemed to have very high likelihood of achieving adequate blood sugar control, while other GLP-1s have been deemed highly likely