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Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets

Acknowledgements The authors would like to thank the experimental apparatus and technical support provided by the Key Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine

The peptide community discussions are filled with stories of researchers who abandoned protocols prematurely because they rushed titration, and the pattern is remarkably consistent across compounds