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The Hayflick limit and why telomere length matters In 1961, Leonard Hayflick demonstrated that normal human cells have a finite replication capacity of approximately 50 to 70 divisions, after which they enter senescence or apoptosis

For example, whereas sulphide-oxidising activity is virtually undetectable in nervous system cells, colonocytes display high expression and activity of SOP enzymes, 131,132,133 consistent with the high H 2 S concentrations that result from gut microbial metabolism