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AMG 133 (maridebart cafraglutide) is a bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR antagonist antibody to two GLP-1 analogue agonist peptides using amino acid linkers

There's no evidence saying these drugs cause C cell hyperplasia in humans, so the FDA gave it a black box warning until we know more

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The GI societies also noted the impact of stopping this medication prior to upper gastrointestinal endoscopy or other moderate to deep sedated procedures is unknown at this time. As clinical gastroenterologists and hepatologists, we are very familiar with safety issues regarding the performance of endoscopy in our patients suffering from gastroparesis, as well as unexplained nausea, vomiting and epigastric pain, particularly in emergency situations, the GI societies wrote